Poster Hall

A multicentre survey of vancomycin therapeutic drug monitoring practice in Austria and Germany

Minichmayr IK1, Uster DW2, Fellhauer M3, König C4, Langebrake C5, Wicha SG2 1Dept. of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; 2Dept. of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Germany; 3Hospital Pharmacy, Schwarzwald-Baar Hospital, Villingen-Schwenningen, Germany; 4Hospital Pharmacy and Dept. of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; 5Hospital Pharmacy and Dept. of Stem Cell Transplantation, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

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A new algorithm optimized for initial dose settings of vancomycin using machine learning

Imai S1, Takekuma Y2, Kashiwagi H1, Miyai T3, Sugawara M1,2 1. Faculty of Pharmaceutical Sciences, Hokkaido University, 2. Department of Pharmacy, Hokkaido University Hospital, 3. Graduate School of Life Science, Hokkaido University

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A Novel UPLC-MS/MS Method For Plasma Antiepileptic Drug Analysis For Clinical Research

Balloch SA, Calton LJ, Hammond GW

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A rapid analytical method using an LC-MS/MS for quantitation of serum tocilizumab and its clinical application

Mochizuki T 1, Shibata K 1, Naito T 1, Shimoyama K 2, Ogawa N 2, Kawakami J 1
1 Department of Hospital Pharmacy, Hamamatsu University School of Medicine
2 Department of Rheumatology, Hamamatsu University School of Medicine

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A simple and rapid Liquid chromatography-tandem mass spectrometry method for betamethasone measurement in human plasma venous blood and umbilical cord blood

Kupa LVK3, Romano P1,2, Almeida REP1,2, Duarte NJC1,2, Chalom MY1. 1Central Laboratory Division, 2Laboratório de Investigação Médica (LIM 03), 3Laboratório de Investigação Médica (LIM 17), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil

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A simple and rapid UHPLC-MS/MS method for measurement of hydroxychloroquine in saliva

Seraphim JC1, Amaral ACS1, Kupa LVK1, Romano P2,3, Chalom MY2, Almeida REP2,3, Duarte NJC2,3, Carvalho VM4, Silva CA1, Bonfa E1Rheumatology Division Hospital das Clínicas HCFMUSP 2 , Central Laboratory Division, 3Laboratório de Investigação Médica (LIM 03), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo 4Grupo Fleury, São Paulo, SP, BR.

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A Study To Develop An Alternate Sampling Strategy To Measure Rifampicin Concentration – To Facilitate This Service In Resource Limited Settings

Santhosh S1, Winston B1, Christopher DJ2, Prabha R1, Mathew S1, Mohan D2, Mathew BS1
1Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology, CMC Vellore.
2Department of Pulmonary Medicine, CMC Vellore.

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Accuracy of documented administration times for intravenous antimicrobial drugs

Roydhouse S.A.1, 2, Carland J.E.1, 2, Debono D.S.3, Baysari M.T.4, Staciwa A.5, Sandhu A.5, Day R.O.1,2,6, Stocker S.L.1, 2
1St Vincent’s Clinical School, The University of New South Wales, Sydney, Australia
2Department of Clinical Pharmacology and Toxicology, St Vincent’s Hospital Sydney, Sydney, Australia
3Centre for Health Services Management, Faculty of Health, The University of Technology Sydney, Sydney, Australia
4Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
5Pharmacy Department, St Vincent’s Hospital Sydney, Sydney, Australia
6School of Medical Sciences, The University of New South Wales, Sydney, Australia

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Assay Performance for a Newly Reformulated Immunoassay to Quantify Cyclosporine in Whole Blood

Schneider, R, Bhandari, M, Lavin, Y.
Abbott Diagnostics

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Assessment Of KRIBIOLISATM ECULIZUMAB ELISA On The ADLTISTM Analyzer

Outeda-Macías M, Salvador-Garrido P, Elberdín-Pazos L, Martín-Herranz I.
Pharmacy Department. A Coruña University Hospital Complex. Área Sanitaria da Coruña e Cee. A Coruña. Spain.

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Assessment of saliva as an alternative matrix for therapeutic drug monitoring of hydroxychloroquine in systemic lupus erythematosus

Kupa LVK1, Duarte NJC2,3, Seraphim JC1, Duarte AJS2,3, Romano P2,3, Martins VAO1, Pedrosa TN1, Pasoto SG1, Aikawa NE1, Carvalho VM4, Silva CA1, Bonfa E1.
1Rheumatology Division, 2Central Laboratory Division, 3Laboratório de Investigação Médica (LIM 03), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 4Grupo Fleury, São Paulo, SP, Brazil

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Biomonitoring Studies from Two Diverse Populations: Significance in Pregnancy

1, 2 Anetor, J. I*. 1 MacDonald A, 1Huang D, 3Ikeh- Tarawali, P, 4Charles- Davis, M. A., 5Arowojolu, A; 1Kinniburgh, D. W
1Alberta Centre For Toxicology, Cumming School of Medicine, University of Calgary, Canada
2Laboratory for Toxicology & Micronutrient Metabolism, Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan
3Department of Chemical Pathology, Niger Delta University, Bayelsa, State, Nigeria
4Endocrinology Unit, Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria
*Correspondence

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Characterisation of tacrolimus demethylated metabolites using high resolution mass spectrometry: an open ring structure?

Aouad H.1, Sauvage FL.1, Di Meo F.1, Marquet P.1,2, Essig M.3
1IPPRITT UMR-1248 INSERM, Faculty of Medicine, Limoges, France
2Department of pharmacology and toxicology, CHU Limoges, Limoges, France
3APHP, Ambroise Paré Hospital, Nephrology Departement, 92100 Boulogne Billancourt, France

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Clinical validation study to derive conversion factors from capillary blood to plasma concentration for mirtazapine, quetiapine and norquetiapine

Stern M1, Giebels M2, Fey T2, Lübking M3, Alferink J3, Hempel G1
1 Department of Pharmaceutical and Medical Chemistry – Clinical Pharmacy, University of Münster, Corrensstraße 48, 48149 Münster, Germany
2 Geriatric Psychiatry, LWL-Klinik, Friedrich-Wilhelm-Weber-Straße 30, 48147 Münster, Germany
3 Damian-Klinik, Alexianer Münster GmbH, Alexianerweg 9, 48163 Münster, Germany

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Clozapine TDM: A Comparison Of LC/MS/MS, Point Of Care And Immunoassay

Christian Cooper1, Kayleigh Davis1, Matthew Atkins2, David Taylor2, Philip McGuire3, Irina Baburina4, Salvatore Salamone4, Dave Berry1
1Viapath Toxicology,Kings College Hospital, 2Maudsley Hospital , 3Institute of Psychiatry, King’s College, 4Saladax Biomedical, Inc.

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Comparison between Toxtyper™ and LC-Quadrupole-Time-of-Flight-MS in post-mortem toxicology

Martial LC[1], Olyslager E[2], Den Burger JCG[1], Wieferink J[2], Franssen EJF[1], Van Gendt-de Jong LAA [2].
[1] Department of Hospital Pharmacy, OLVG, Amsterdam, The Netherlands; [2] Department of Hospital Pharmacy, Gelre Ziekenhuizen, Apeldoorn/Zutphen, The Netherlands.

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Correlation of concentration of Azathioprine metabolites and clinical outcome in patients with autoimmune bullous disease – a pilot study

M. Steffi Aswini Maria, Ratna Prabha, Binu S Mathew, Sumith K. Mathew, Susanne Pulimood1,Dincy Peter C.V1, Gauri Mahabal1
Department of Pharmacology and Clinical Pharmacology,
1Department of Dermatology, CMC Vellore

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Determination of EtG and EtS in human urine and serum by LC-MS/MS

Ye J., Zhang X., Huang D. Y., Kinniburgh D. W.
Alberta Centre for Toxicology, Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

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Development and validation of measuring hematocrit levels in dried blood spots using Near-Infrared spectroscopy

Daan van de Velde, BSca; Jordy L. van der Graaf, BSca; M. Boussaidia; R. Huismana; Dennis A. Hesselink, PhDb; H. Russcher, PhDc; Erik van Maarseveen, PhDd; Brenda C.M. de Winter, PhD a
aDepartment of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the Netherlands
bDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
cDepartment of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands
dDepartment of Hospital Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands

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Development of a population pharmacokinetic meta-model for everolimus from simulated database

Nanga TM.1, Bouriah S.1, Woillard JB.2, Rousseau A.1, Marquet P.2, Musuamba FT.3, Prémaud A.1
1IPPRITT UMR-1248 INSERM, Université de Limoges – Limoges (France)
2IPPRITT UMR-1248 INSERM, CHU de Limoges, Université de Limoges – Limoges (France)
3Federal Agency for Medicines and Health Products – Brussels (Belgium)

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Dilute-and-shoot determination of THC-COOH and THC-COOH-glucuronide in human serum by LC-MS/MS

Ye J., Zhang X., Huang D. Y., Kinniburgh D. W.
Alberta Centre for Toxicology, Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

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Disposable Sensor Chips Using Molecularly Imprinted Polymers Enables Easy Determination of Blood Level of Drugs

Aaryashree, Yuuto Takeda, Momoe Kanai, Yasuo Yoshimi
Department of Applied Chemistry, Shibaura Institute of Technology and Technology

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Dose optimisation of cefotaxime in critically ill patients: a population pharmacokinetic study

Authors: Roelofsena  E. E. de Winterb B.C.M., Abdullab A., Endemanc H., Dijkstrad A., Mullere,f A. E., Kochb B. C.P.
a Department of Hospital Pharmacy, Haaglanden Medical Centre, The Hague, The Netherlands.
b Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.
c Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands.
d Department of Intensive Care, Maasstad Hospital, Rotterdam, The Netherlands.
e Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
f Department of Medical Microbiology, Haaglanden Medical Centre, The Hague, The Netherlands.

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Early Tacrolimus Concentrations Are Influenced by Genetic and Clinical Factors in Chinese Lung Transplant Patients

Du W1, Wang X1, Zhang D1, Chen W1, Wang X1, Zhang X1, Chen W2, Li P1
1 Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China
2 Department of Lung Transplantation, China-Japan Friendship Hospital, Beijing, China

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Effect Of Antibiotics-Mediated Microbiota Depletion On Tacrolimus Pharmacokinetics In Mice

Degraeve A1,4, Stillemans G1,2, Moudio S1, El-Hamdaoui H1, Delongie K-A3, Haufroid V2,3, Bindels L4, Elens L1
1Department of Integrated PharmacoMetrics, PharmacoGenomics and PharmacoKinetics, LDRI, UCLouvain, Belgium
2 Louvain Centre for Toxicology and Applied Pharmacology, IREC, UCLouvain, Belgium
3 Department of Clinical Chemistry, Saint-Luc university clinics, Belgium
4 Metabolism and Nutrition Research Group, LDRI, UCLouvain, Belgium

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Effect of the POR*28 and CYP3A5*1 genotype on the blood concentration of tacrolimus in renal transplant recipients

Suzuki Y.1, Yoshihashi T.1, Takahashi K.2, Oda T.2, Homma M.1,3
1Department of Pharmacy, University of Tsukuba Hospital
2Department of Gastrointestinal and Hepato-biliary-pancreatic, and Transplantation Surgery, Faculty of Medicine, University of Tsukuba
3Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba

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Estimation of the under area the concentration-time curve of polymyxin B based on limited sampling concentrations in Chinese patients with severe pneumonia

Estimation of the under area the concentration-time curve of polymyxin B based on limited sampling concentrations in Chinese patients with severe pneumonia
Wenqian Chen1, Huifang Liu1, Qianlin Wang2, Xiaoxing Wang1, Xudong Kong1, Xiaoxue Wang1, Xianglin Zhang1, Qingyuan Zhan2,Pengmei Li1*
(1.Department of pharmacy, China-Japan Friendship Hospital, Beijing 100029; 2. Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029)

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Evaluation of the correlation between circulating tumor DNA dynamics and lung cancer chemotherapy efficacy

Zhiyao Chena,‡, Shichao Zhanga,‡, Cheng Dingb, Chang Lib, Jun Chenb, Jun Zhaob, * and Liyan Miaoa, *
a Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, PR China.
b Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, PR China.
These authors contributed equally to this work.
*Author for correspondence.

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First report on brorphine: the next opioid on the deadly new psychoactive substances’ horizon?

Nick Verougstraete1,2, Marthe Vandeputte1, Cathelijne Lyphout3, Annelies Cannaert1, Fabian Hulpia4, Serge Van Calenbergh4, Alain G. Verstraete2,5, Christophe Stove1
1: Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
2: Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
3: Emergency Department, Ghent University Hospital, Ghent, Belgium
4: Laboratory for Medicinal Chemistry, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
5: Department of Diagnostic Sciences, Ghent University, Ghent, Belgium

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First results of the CYPTAC’H study: influence of CYP3A5 polymorphism of donor and recipient on Tacrolimus exposure in liver transplant recipients

Verdier Mc1,2,3, Houssel P4, Lemaitre F1,2,3, Verin M1, Tron C1,2,3, Lalanne S1,2,3, Renac V5, Boudjema K4,6, Bellissant E1,2,3
1 CIC 1414 (Clinical Investigation Center), INSERM, Rennes, France.
2 Clinical Pharmacology Department, CHU Rennes, Rennes, France.
3 Experimental and Clinical Pharmacology Laboratory, Univ Rennes, Rennes, France.
4 Department of Hepatobiliary and Digestive Surgery, University Hospital, Rennes 1 University, Rennes, France.
5 Etablissement Français du Sang Bretagne, HLA Laboratory, Rennes, France.

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High Throughput Automated Sample Preparation and Analysis of Drugs of Abuse in Human Urine Using LC-MS/MS

Zhang X, Ye J, Huang D.Y, Kinniburgh D.W.
Alberta Centre for Toxicology, University of Calgary, Calgary, Alberta, Canada

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Impact of the preanalytical practices on the uracil and dihydrouracil stability for the diagnosis of dihydropyrimidine dehydrogenase deficiency

Maillard M.1, Langevin M.2, Ciccolini J.3, Etienne MC.4, Tafzi N.5, Launay M.6, Richard D.7, Gautier E.8, Royer B.9, Narjoz C.10, Haufroid V.11, Bouges H.4, Picard N.5 , Barin-Le Guellec C.2,12, Thomas F.1,13
1Centre de Recherches en Cancérologie de Toulouse, Inserm UMR1037, Université Paul Sabatier, Toulouse, France, 2Université de Tours, Tours, France, 3AP-HM Hôpital La Timone, Marseille, France, 4Centre Antoine Lacassagne, Nice, France, 5CHU de Limoges, Limoges, France, 6CHU de Saint-Etienne, Saint-Etienne, France, 7CHU de Clermont-Ferrand, Clermont-Ferrand, France, 8CHU de Dijon-Bourgogne, Dijon, France, 9CHU Jean-Minjoz, Besançon, France, 10Hôpital Européen Georges Pompidou, Paris, France, 11Cliniques Universitaires Saint Luc, Bruxelles, Belgique, 12CHU Bretonneau, Tours, France, 13Institut Claudius Regaud, IUCT-Oncopole, Toulouse, France

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Individualized dosing with high inter-occasion variability is correctly handled with model-informed precision dosing – using rifampicin as an example

Lina Keutzer and Ulrika SH Simonsson
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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Influence of allopurinol on thiopurine associated toxicity: a retrospective population-based cohort study

Houwen J,1,2 Egberts A, 1,2 de Boer A,2,3 Maarseveen E,1 Houwen R,4 Lalmohamed A.1,2
1University Medical Center Utrecht, Department of Clinical Pharmacy Utrecht, Netherlands
2Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands
3Dutch Medicines Evaluation Board (CBG/MEB), Utrecht, Netherlands
4University Medical Center Utrecht, Department of Paediatric Gastroenterology, Utrecht, Netherlands

 

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Influence of CYP3A4*1 and CYP3A4*22 genetic polymorphisms on MeltDose® tacrolimus pharmacokinetics in adult renal transplant patients

Salvador-Garrido P, Outeda-Macías M, Fernádez-Rivera C1, Elberdin-Pazos L, Martín-Herranz I.
Pharmacy Service. 1Nephrology Service. A Coruña University Hospital. Área Sanitaria da Coruña e Cee.  A Coruña. Spain.

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Internal Quality Control Evaluation of Therapeutic Drug Monitoring of Lamotrigine by Westgard Multi-rule Theory

Wu Y, Li H, Wang L, Deng X, Wang X, Shi T
Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001,P.R. China

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Is there a need to monitor colistin exposure in critically ill patients?

Mathew SK, Rao SV*, Prabha R, Aruldhas BW, Subramani K*, Mathew BS
Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India, *Surgical Intensive Care Unit and Division of Critical Care, Christian Medical College, Vellore, Tamil Nadu, India

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Isavuconazole In Pediatric Patients With Onco-Haematologic Diseases And Haematopoietic Stem Celltransplantation

M. Molinaro1, N. Decembrino2, B.M. Goffredo3, S. De Gregori1, I. Giardini1, S. Cairoli3, K. Perruccio4, A. Colombini5, E. Calore6, P. Muggeo7, E. Soncini8, A. Comelli9, L. Scudeller11, M. Zecca2, S. Cesaro10
1Clinical & Experimental Pharmacokinetics Unit – Fondazione IRCCS Policlinico San Matteo – Pavia
2Dept. of Hematology/Oncology – Fondazione IRCCS Policlinico San Matteo – Pavia
3Lab. of Metabolic Pathology – Ospedale Pediatrico Bambino Gesù – Roma
4Div. of Pediatric Hematology – University Hospital of Perugia – Perugia
5Pediatric Hematology/Oncology – Fondazione Monza e Brianza per il Bambino e la Mamma – Monza
6Pediatric Hemato-Oncology, Dept. of Women’s and Children Health, University Hospital of Padova – Padova
7Dept. of Pediatric Oncology and Hematology, University Hospital of Policlinico – Bari
8Pediatric Hematology/Oncology – Spedali Civili – Brescia
9Dept. of Infectious and Tropical Diseases – Spedali Civili – Brescia
10Clinical Epidemiology and Biometric Unit, Scientific Direction – Fondazione IRCCS Policlinico San Matteo – Pavia
11Pediatric Hematology/Oncology – Azienda Ospedaliera Universitaria Integrata – Verona

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Large variability of unbound active fraction of ceftriaxone in contrast to ciprofloxacin in plasma of critically ill patients

Tim Ewoldt1, Alan Abdulla2, Diederik Gommers1, Anouk Edwina Muller3,4, Henrik Endeman1, Birgit Koch2
1Erasmus University Medical Center, Department of Intensive Care, Rotterdam, Netherlands,
2Erasmus University Medical Center, Department of Hospital Pharmacy, Rotterdam, Netherlands,
3Erasmus University Medical Center, Department of Medical Microbiology and Infectious Diseases, Rotterdam, Netherlands,
4Haaglanden Medical Center, Department of Medical Microbiology, Den Haag, Netherlands

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Lowered Antioxidant Status In Pregnant Women On Iron Supplements: Significance And Candidacy Of Iron For Therapeutic Drug Monitoring In Pregnancy

Anetor JI* 1,2, Adeleke FN2, Ajose OA 3, Olaniyan-Taylor GO1, Fasola FA 4, Anetor GO 5
1Alberta Centre For Toxicology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Laboratory for Toxicology and Micronutrient Metabolism, Chemical Pathology Department, College of Medicine, University of Ibadan, Nigeria
3Department of Chemical Pathology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
4Department of Haematology, College of Medicine, University of Ibadan, Nigeria
5Health Education Unit, Department of Human Kinetics & Health Education, National Open University of Nigeria (NOUN), Abuja, Nigeria
*Correspondence

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Microsampling in transplant recipients: time to reshape tacrolimus from trough concentration to AUC?

Florian Lemaitre1,2, Camille Tron1,2, Sebastien Lalanne1,2, Marie-José Ferrand-Sorre1,2 et Marie-Clémence Verdier1,2
1Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, F-35000 Rennes, France
2INSERM, Centre d’Investigation Clinique, CIC 1414, F-35000 Rennes, France

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Model-informed precision dosing of everolimus: external validation in adult renal transplant recipients

Zwart TC (1), Moes DJAR (1,2), van der Boog PJM (3), van Erp NP (4), de Fijter JW (3), Guchelaar HJ (1,2), Keizer RJ (5), ter Heine R (4)
(1) Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, Leiden, The Netherlands
(2) Leiden Network for Personalized Therapeutics, Leiden, The Netherlands
(3) Leiden University Medical Center, Department of Internal Medicine (Nephrology), Leiden, The Netherlands
(4) Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands
(5) Insight RX, San Francisco, CA, USA

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Model-informed simulation for optimal vancomycin dosage in pediatric patients with febrile neutropenia: implication of augmented renal clearance on appropriate dosing

Shimamoto Y1, Mizuno T2,3, Verstegen R1, Allen U4, Ito S1,5
1 Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
2 Division of Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA
3 Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, USA
4 Division of Infections Disease, The Hospital for Sick Children, Toronto, Canada
5 Department of Pediatrics, University of Toronto, Toronto, Canada

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Molecular Networking Approach combined with MetWork web server for Toxicology and TDM Application

Bourgogne E1,2, Grondin C 3, Magreault S4, Beauxis Y1, Genta-Jouve G1,5
 1 Université de Paris, faculté de Pharmacie, UMR 8038, Paris, France, 2 Hôpital Saint Antoine, Paris, France, 3 Hôpital Lariboisière, Paris, France 4 Hôpital Jean Verdier, Paris, France, 5 USR 3456 CNRS LEEISA, Guyane, France

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MRP4 is responsible for the efflux transport of mycophenolic acid b-D glucuronide (MPAG) from hepatocytes to the blood

BERTHIER Josepha,b, BENMAMERI Mehdia, SAUVAGE François-Ludovica, FABRE Gabina, CHANTEMARGUE Benjaminc, MARQUET Pierrea,b, TROUILLAS Patricka,d , PICARD Nicolasa,b , SAINT-MARCOUX Francka,b
a INSERM, UMR 1248, Univ. Limoges, rue du Pr Descottes, F-87000 Limoges, France;
b CHU Limoges, Service de pharmacologie, toxicologie et pharmacovigilance, rue du Pr Descottes, F-87000 Limoges, France;
c INSILIBIO, 1 avenue Ester Technopôle, 87069 Limoges Cedex, France;
d RCPTM, Univ. Palacký of Olomouc, tr. 17. listopadu 12, 771 46 Olomouc, Czech Republic

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MTXPK.org: A clinical decision support tool evaluating high-dose methotrexate pharmacokinetics to inform post-infusion care and use of glucarpidase

Taylor, Z.L.1,2,3, Mizuno, T. 3,4, Punt, N.C.5, Baskaran, B.6, Navarro Sainz, A.6, Shuman, W.6, Felicelli, N.6, Vinks, A.A.2,3,4, Heldrup, J.7, Ramsey, L.B. 2,3,4
1 Department of Molecular, Cellular, and Biochemical Pharmacology, University of Cincinnati, Cincinnati, OH
2 Division of Research in Patient Services, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
3 Division of Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
4 Department of Pediatrics, University of Cincinnati, Cincinnati, OH
5 Medimatics, Maastricht, The Netherlands
6 Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
7 Department of Pediatrics Oncology, Lund University Hospital, Lund, Sweden

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Nephrotoxicity of TDM-guided amphotericin B infusions in intensive care patients

Geersing, TH1; Van der Voort, PHJ2; Spronk, PE3; Franssen, EJF1
1Department of Clinical Pharmacy, OLVG, Amsterdam, The Netherlands
2Department of Intensive Care, UMCG, Groningen, The Netherlands
3Department of Intensive Care Medicine, Gelre hospitals Apeldoorn, Apeldoorn, The Netherlands

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Optimized Administration of Voriconazole and Therapeutic Drug Monitoring in Children and Adolescents: A Single-Centre Retrospective Experience from China

Yan M , Zou Y, Tang D, Wang Y, Xiao YW, Zhao YC, Wang F, Zhang BK, Xiang DX
The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Oral solution and sustained-release tablets of sodium valproate causing significant difference on C0/D ratio of valproic acid in children with epilepsy

Ze-Yue Xua,b,†,‡, Hong-Li Guoa,, Ling Lia,b,, Xia-Jinga, Ze-Jun Xua, Jin-Chun Qiua, Xiao-Peng Luc, Feng Chena,*, Jing Xua,*, Xuan-Sheng Dingb
a Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, China
b School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
c Department of Neurology, Children’s Hospital of Nanjing Medical University, Nanjing, China

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Pharmacokinetic/pharmacodynamic analysis of lenvatinib in patients with hepatocellular carcinoma

Noda S1, Wakasugi Y1, Yabuta N1, Sudou M1, Hira D1,2, Iida H3, Osaki R4, Fujimoto T4, Tani M3, Andoh A4, Morita SY1, Terada T1
1Department of Pharmacy, Shiga University of Medical Science Hospital
2College of Pharmaceutical Sciences, Ritsumeikan University
3 Department of Surgery, Shiga University of Medical Science Hospital
4Department of Gastroenterology, Shiga University of Medical Science Hospital

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Phenotyping uracil and 5-fluorouracil metabolism using LC-MS/MS to prevent the toxicity and adjust the dose of fluoropyrimides

Tafzi N a, Picard N b, Woillard JB b, Fleytoux A a, Marquet P b.
aDepartment of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges (France)
bDepartment of Pharmacology, Toxicology And Pharmacovigilance, CHU Limoges, Limoges, (France) and University of Limoges, Inserm, UMR IPPRITT 1248, Limoges(France)

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Point of Care Testing (POCT) of Antipsychotic Drugs

Salvatore J. Salamone1, Mary Rose Hilaire1, Nathan A. Siegfried1, Ashwini Sumanth1, Dan Kozo1, Regina Gill1, Kristin DiStefano1, Rebecca Harney1, Justin Jarrah1, Jodi Courtney1, Irina Baburina1
1Saladax Biomedical, Inc.

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Population pharmacokinetic model and external validation of meropenem in severe pulmonary infected patients

Yan M , Zou Y, Xiao YW, Wang F, Luo H , Zhang BK
The Second Xiangya Hospital of Central South University, Changsha, Hunan , China

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Population pharmacokinetics and clinical outcome of nivolumab in Japanese patients with non-small cell lung cancer

Makiko T 1, Tomoyuki M 2, 3, Kei I1, 4, Hiroyuki O 1, Masaki H 1, Hiroaki I 1, Nobuyuki M 1, Masaaki E 5, Shoji F 4, Keisuke T 6 and Tohru H 1
1 Department of Pharmacy, Kobe City Medical Center General Hospital, Kobe, Japan.
2 Division of Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
3 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
4 Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
5 Department of Clinical Laboratory Technology, Kobe City Medical Center General Hospital, Kobe, Japan.
6 Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.

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Population Pharmacokinetic analysis of tacrolimus combined with Wuzhi capsule in Chinese kidney transplant recipients

Jing Yan1,2, Hongwei Peng1,2,#
1Department of Pharmacy, First Affiliated Hospital of Nanchang University, China;
2Department of Pharmacy, Medical School of Nanchang University, Nanchang, China;
#Correspondence

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Post-mortem analysis of fentanyl after an overdose with more than 40 fentanyl patches

Bethlehem, PharmDa; L.E.J. Peeters, PharmDa,b; I.T. Vleut, MSca; G.E. Tan, MDc; E.A. Croes MD PhD d
aErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, The Netherlands
bErasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, The Netherlands
cPublic Health Service (GGD) region Utrecht
d Trimbos Institute, Utrecht, The Netherlands

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Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients

 Yan M, Zhao YC, Lin XB, Zhang BK
The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Reasons for Non-Adherence in Liver Transplant Patients in Uruguay

Noceti O1; Deleón N1; Woillard J-B2; Viñoly MC1; Gerona S1.
1Liver Diseases Department, National Center for Liver Transplantation, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay.
2U1248 INSERM, IPPRITT Univ. Limoges, France.

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Sampling strategy and analysis of cannabis, alcohol and nicotine biomarkers in pregnant women pre- and post-legalization in Alberta, Canada

Zhang, X [1], MacDonald, A.M.[2], Ye, J [1], Huang D.Y.[1],  Charleton, C.[3], Huestis, M.[4] and Kinniburgh, D.W.[1]
[1]Alberta Centre for Toxicology (ACFT), Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, [2] Health and Environments Research Centre Laboratory, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada, [3]Public Health Laboratories, Alberta Health Service, Edmonton, Alberta, Canada, [4]Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA

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Simultaneous LC-MS/MS quantification of creatinine, iohexol and five immunosuppressants in renal transplant recipients using volumetric dried blood spot sampling: analytical validation

Zwart TC (1), Metscher E (1), Gokoel SRM (2), van der Boog PJM (2), de Fijter JW (2), Guchelaar HJ (1,3), Swen JJ (1,3), de Vries APJ (2), Moes DJAR (1,3)
(1) Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
(2) Department of Internal Medicine (Nephrology and LUMC Transplant Center), Leiden University Medical Center, Leiden, The Netherlands.
(3) Leiden Network for Personalized Therapeutics, Leiden, The Netherlands.

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Simultaneous Quantification Of Benznidazole, Atazanavir And Efavirenz By UHPLC-MS/MS In Plasma Of Patients Coinfected With Chagas’ Disease And HIV/AIDS

Pérez Montilla, CA1; Fleitas, UE2; Marson, ME2; Fernández, ML3; García Bournissen, F4
1Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas, Consejo Nacional de Investigaciones Científicas y Técnicas (IMIPP-CONICET), Servicio de Parasitología y Chagas, Hospital de Niños “Dr. Ricardo Gutiérrez”. Buenos Aires, Argentina. 2Área de Toxicología, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP-CONICET). Buenos Aires, Argentina. 3Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”, ANLIS “Dr. Carlos G. Malbrán”, Hospital de Infecciosas “Dr. Francisco Javier Muñiz”. Buenos Aires, Argentina. 4Division of Paediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University. London, Ontario, Canada.

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Simultaneous screening of over the counter and commonly used prescription drugs from a single blood sample with a biochip array on the Evidence Investigator analyser

Darragh J., Dhanoa S., Rodríguez M.L., McConnell R.I., FitzGerald S.P.
Randox Toxicology Ltd., Crumlin, United Kingdom

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Study to develop Alternate Sampling Strategies to measure tacrolimus and creatinine – to facilitate domiciliary care of transplant patients: an interim analysis

Mathew BS, Sumith Mathew, Santosh Varughese*, David VG*, Jeyaseelan L$, Ratna Prabha, Blessed Winston, John GT#
– Dept.of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India
* – Dept. of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India
$ – Dept. of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India
# – Kidney Health Service, Royal Brisbane and Women’s Hospital, Brisbane, Australia

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Substantially increased plasma coproporphyrin-I concentrations associated with OATP1B1*15 allele in Japanese general population

Suzuki Y1, Sasamoto Y1, Koyama T2, Yoshijima C1, Ohno K1
1Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Japan
2Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Japan

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Subtherapeutic triazole concentrations as result of a drug-drug interaction with lumacaftor/ivacaftor

Smeets TJL1, van der Sijs IH1, de Winter BCM1, Ruijgrok EJ1
1Department of Hospital Pharmacy, Erasmus MC University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands

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Tacrolimus Bayesian dose adjustment in a large population of paediatric renal transplant recipients

P. Marquet1,2, F. Cros1, L. Micallef1, E. Jaqz-Aigrain, J.B. Woillard1,2, C. Monchaud1,2, F. Saint-Marcoux1,2, J. Debord1,2.
1 Department of Pharmacology and Toxicology, CHU Limoges, Limoges, France.
2 IPPRITT, Univ. Limoges, INSERM, Limoges, France.
3 Department of Paediatric Pharmacology and Pharmacogenetics, Robert Debré Hospital, APHP, Paris, France; University Paris Diderot Sorbonne Paris Cité, Paris, France; Clinical Investigation Center CIC1426, INSERM, Paris, France.

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The clinical applicability of monitoring antihypertensive drug levels in blood

Laura E.J. Peeters, PharmDa,b, Lida Feyz, MDc; Eric Boersma, PhDc, Joost Daemen, MD, PhDc; Teun van Gelder MD, PhDa,b; Birgit C.P. Koch PharmD, PhDb; Jorie Versmissen, MD, PhDa
a  Erasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, The Netherlands
Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, The Netherlands
c  Erasmus MC, University Medical Center Rotterdam, Department of Cardiology, The Netherlands

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The diagnosis and treatment of ethylene glycol poisoning

Jenkins A,1, 2 Amato R1 and Xiong Y2
1Quest Diagnostics, Marlborough, MA and 2UMass Memorial Medical Center, Worcester, MA

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The dose-related reference range – a new approach with improved predictive quality

Endres K, Haen E
Clinical Pharmacology, Departement of Psychiatry and Psychotherapy and Departement of Pharmacology and Toxicology at the University of Regensburg; Institut AGATE, Pentling

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The genetic screening information and outcomes: Case series reports at the Queen Savang Vadhana Memorial Hospital

Tewthanom K1 Tunwongsa K 2
1 Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand, 73000
2 Department of Pharmacy, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand 20110

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The Selection of P2Y12 Receptor Inhibitor for Patients with CYP2C19 Intermediate metabolizers After Percutaneous Coronary Intervention

Wu Y1, Yu D2, Zhang L2, Sun Q2, Yu H2, Shi T1
1Department of Pharmacy, 2Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001,P.R. China

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The Trends Of Voriconazole Plasma Trough Concentration Affected By Rifampin Induction Effects: Case Series

M.S. Ban, M.D., B. Kim, M.D., J.Oh, M.D., Ph.D, S. Lee, M.D., Ph.D., IJ.Jang, M.D., Ph.D

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Therapeutic drug monitoring of 5-fluorouracile: a complementary approach to pre-therapeutic detection of dihydropyrimidine dehydrogenase deficiency to optimize chemotherapy

Tron Ca, Vermond Na, Lièvre Ab, Le Sourd Sc, Edeline Jc, Jary Ad, Quillien Ve, Bellissant Ea, Verdier MCa, Lemaitre Fa
aDepartment of clinical and biological pharmacology and pharmacovigilance, pharmacoepidemiology and drug information center, Rennes University Hospital – Rennes (France)
bDepartment of gastro-enterology, Rennes University Hospital – Rennes (France)
cDepartment of medical oncology, Centre Eugène Marquis – Rennes (France)
dDepartment of pharmacy, Centre Eugène Marquis – Rennes (France)
eDepartment of biology, Centre Eugène Marquis -Rennes (France)

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Therapeutic Drug Monitoring of Mycophenolate Mofetil in >1,000 paediatric renal transplant patients using an online expert system

Ludovic Micallef, Caroline Monchaud, Jean-Baptiste Woillard, Franck Saint-Marcoux, Pierre Marquet
Department of Pharmacology and Toxicology, CHU Limoges, France
And the IPPRITT research unit, INSERM, University of Limoges, France

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To determine the serum concentration of vancomycin achieved with doses used in current practice in patients undergoing intermittent hemodialysis

Dhruva A1, Mathew S1, Winston B1, Prabha R1, David V2, Mathew B1
1. Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore
2. Department of Nephrology, Christian Medical College, Vellore

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Towards precision dosing of vancomycin in critically ill patients: An evaluation of the predictive performance of pharmacometric models in ICU patients

Cunio C.1, 2, Uster D.3 Carland J.E.1, 2, Buscher H.1,4, Liu, Z5, Brett J.1, 2, Stefani M.1, 2, Jones G.1,6 Day R.O.1,2,7, Wicha S.3Stocker S.L.1, 2
1St Vincent’s Clinical School, The University of New South Wales, Sydney, Australia.
2Department of Clinical Pharmacology and Toxicology, St Vincent’s Hospital Sydney, Sydney, Australia
3University of Hamburg, Institute of Pharmacy, Hamburg, Germany
4Intensive Care Medicine, St Vincent’s Hospital Sydney, Sydney, Australia
5Stats Central, The University of New South Wales, Sydney, Australia
6Sydpath, St Vincent’s Hospital Sydney, Sydney, Australia
7School of Medical Sciences, The University of New South Wales, Sydney, Australia

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Toxicokinetics And Muscle-Related Toxicity Of Atorvastatin in vitro

Hoste E1,2, Paquot A3, Panin N2, Giulio G. Muccioli3, Haufroid V2,4, Elens L1.
1 Integrated PharmacoMetrics, pharmacoGenomics and pharmacokinetics, LDRI, UCLouvain, Belgium.
2 Louvain Center for for Toxicology and Applied Pharmacology, IREC, UCLouvain, Belgium.
3 Bioanalysis and Pharmacology of Bioactive Lipids, LDRI, UCLouvain, Belgium.
4 Department of Clinical Chemistry, Saint-Luc university clinics, Belgium

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Toxicological Safety Assessment Of Novel Carbohydrazides: An Antitubercular Agent

Ravinesh Mishra1,2*, Anees A Siddiqui2
1School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi (Solan), Himachal Pradesh-173 205, India; 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.

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Volumetric Absorptive Microsampling (VAMS) As An Alternative Tool For Tacrolimus And Mycophenolic Acid Tdm

Paniagua-González L1, Díaz-Louzao C2, Lendoiro E1, Otero-Antón E3, Cadarso-Suárez C2, López-Rivadulla M1, Cruz A1, de-Castro-Ríos A1
1Toxicology Service, Institute of Forensic Sciences, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
2Department of Statistics, Mathematical Analysis and Optimization, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
3Abdominal Trasplant Unit, Universitary Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain

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